I've used 5 grains of Bullseye in .45 ACP with boolit weights up to 260 grains. If you manage to load an accidental double charge of that, you shouldn't be reloading.
There are a few worse applications for TB than .45 ACP. Very few.
It never ceases to amaze me how popular such a limited application powder is, especially considering it costs half again as much as a more suitable powder. I would rather use an equal charge of 700X or Red Dot, even if they were the same price as TB. Which they're not.
If I had a small amount (5 lbs or less) of TB, I would probably use it for the only purpose I consider it good for: subsonic cast boolit loads in full size rifle cartridges. If I had more than 5 lbs, it would be for sale.
I don't have any of it though, because I don't consider it suitable enough for any of my applications to be worth the added cost over other powders.
Trail Boss was designed for low velocity, low recoil loads in cartridges like .45 Colt, for cowboy action shooting. But a lot of people seem to misconstrue that as "you cannot fit a double charge in the case" or even worse, "you cannot fit enough in the case to cause a problem." But according to this article, .45 Colt will accept 13.3 grains. That will almost certainly blow up a SAA or clone. Even with the minimum manufacturer published load of 4.5 grains under a 255-260 grain boolit, a double charge of 9 grains will fit in the case and would be well into "Ruger only" category and perhaps beyond.
I recommend that newbie reloaders stop paying the high price for this powder because based on a lot of comments I have read about it on various forums (including this one), it is giving some of you a false sense of security.