Changeling;
I stand by my comments. .22's with solid round noses don't kill well out of a rifle much less out of a revolver with much less velocity. Of course, they kill well with a brain shot but unless they are close, it's a body shot or nothing. When used with a hollow point, particularly in a rifle they kill well at reasonable ranges but they DO tear up meat.
I gave up the .22 rimfire after years of trying to make it work on edible small game. It's just flat marginal for that use (when squirrels did not present a head shot, I took a body shot and often lost them - no hunter wants to have that happen - it's not humane). My squirrel rifle has been a 25/20 for many years. It WORKS.
Handguns are slow velocity performers, in general. However, any centerfire from .32 on up and including the .44's have proven to me to do great work on edible small game if you can shoot. I can and pick my shot. That means, as I clearly stated above, a head shot or "through the slats". There is no meat loss with either.
>>>Bottom line I have done this all my life! <<<
Really? Your comments seem to show a singular lack of experience, but Hey! that's just me.
FWIW
Dale53