I can't add to the great post Doug made and the Lee 310 is one great boolit. Bone is nothing much to worry about once weight is enough.
I do use a harder boolit for the tension and it does not hurt the .44 as far as killing. The .475 thrives on hard lead too but other calibers I use need a softer nose. I still keep the rest of the boolits hard.
One season a buck came across in front, moving fast. He was 76 yards and it was still dim out. As I lead him I seen what looked like a little brush ahead but the gun went off. The deer jumped around to my side and I took him in the neck with the next shot. When I got there I found I had shot an osage orange tree, 10" in diameter with another 10" trunk behind. My boolit went through the first trunk, into the second. Osage is some very tough wood!
I don't put much value on crimp. Friend brought factory cast loads to test in a few .454's. Not BB but another company known for hot loads. They had full profile crimps but it only took one shot to lock a freedom and two with a SRH. Not fun to tap boolits back in with a dowel! Very dangerous. I use the least crimp and depend on tension so not a single one of my loads pulled. I ran one for two cylinders full of hot loads. Even Lee boolits with the chicken scratch grooves hold.
I do not believe in ME or losing energy with a pass through because the boolit works because of energy expended. Make the boolit work and velocity or other figures mean nothing.
I see a difference when range increases. Deer shot to 75 yards or under make 20 to 30 yards with the .44 but at 100, they can make 100 yards but blood trails are good with two holes. Most every deer shot with the .475 drop like a sack of dog poo. Energy IS needed but it is not numbers, it is how the boolit works.
Doug uses softer to generate more energy but that goes against my tension needed because of boolit weight I use. Another reason I use only Fed 150 primers in the .44, keep boolits in until powder burn is going so Doug is 100% correct over that. I don't believe crimp alone can do it. A mag primer will break crimp. Even the dies you use can ruin accuracy by over expanding brass.
Case size determines primers so the .475 and up use a 155 best and the .454 should have LP pockets for it. The .45 Colt is border line and will work with a standard or WLP. Full mag is too much. ACP works best with a SP primer.
I had trouble with the 440 gr from my .500 JRH with too hard, deer going 100-120 yards. I softened half the nose but not pure, 3#of pure and 1# of WW. I dropped a big doe in her tracks. A big 8 point came out, seen her and stamped his feet at her to make her get up but she was down for good. He was in the thick but walked fast through the woods at 50 yards. I pulled a lead and found an opening, shot hit behind his shoulders and he dropped like a hot potato. Not many drop with just a double lung hit so my jaw dropped too.
WV confuses me, they reduced the amount of doe to kill but we can take a doe in gun season but if you kill a buck first you must kill a doe before taking another buck.