I was reading a 1929 article written by Elmer Keith in which he described his famous Keith #5 and the .44 bullet (429421) he used in it. He was using Dupont #80 powder and was achieving 1100 fps or so he thought. While it doesn't appear that Mr. Keith was necessarily what we would call a "handgun hunter" today he did use it to take big game animals of opportunity and seemed to think this combination acceptable for deer. In this article he expressed that he would like to have a better powder to achieve better velocity. From what I've read he was looking for about 1200 fps. I also remember reading somewhere that John Linbaugh said his wife used a .44 Special loaded to about 900 fps to take a cow elk.
Now I'm wonder if we really need the big handguns with 300+ grain bullets for taking deer or not. I'm not a very good shot by the standards of many on this board so about 75 yards is the maximum distance I'd shoot at a deer with my .44 Mag Blackhawk. My everyday load is 10 gr. of Unique with the 429421 bullet which is doing about 1125 fps. Do I really need more that this combination to cleanly take a whitetail?