Many 45ACP pistols will feed reliably and shoot very accurately with 200 grain SWC boolits. H&G 68 and Lyman 452460 are two examples.
My thought is that a 200 grain boolit with a nice sharp shoulder on it would make a very nasty boolit to use for home defense or self defense.
The 45 ACP can push this boolit up near 1000fps with standard pressure loads(according to Hodgdon data site).
I can't think that such a projectile traveling at that speed would do anything but ruin a person's day.
This all depends on your particular handgun's ability to handle the SWC design reliably.
What are your thoughts?