I'm gonna say I am the "Best-Most reliable" person to comment on which semi-auto handgun is "Best-Most reliable" ...LOL
Ok, I just had a George Herter's moment, please forgive me.
From the early 1990s until now, I've owned many different brands and models of semi-auto handguns. CZ, Ruger, 1911, Magnum Research, Taurus PT24/7, S&W, Browning, Sig, Hi-Point, AMT Auto-Mag, Glock, Springfield, ect...ect.
Yeah, I am pretty sure I am not alone in this claim, and others may well have much more experience than me.
With that said, The Ruger P-series guns seemed the "Best-Most reliable" out of the box, in regards to all aspects, but most especially for not being picky about ammo projectile types...which seems to be the Achilles Heel of most semi-auto handguns.
I've sold all my Ruger P-series handguns that I had owned, one of which I used in a pistol league, when I was downsizing. But after a year or so after that auction, Ruger came out with a model 9e, it was so reasonably priced and looked and felt the same as the P-series guns, so I bought one...and it is like all the P-series guns I previously owned, "Best-Most reliable" !!!