For me it was disposing of a Remington Model 788 in 22-250 Remington. I was gifted this rifle and I shot it quite a bit at paper and steel. It was not a very pretty rifle. It was plain Jane all the way but very very accurate. To the point it was so accurate that it became boring to me.
Who knew that many years later I would get into calling and hunting coyotes out here in the Las Vegas area. The 22-250 would have been a perfect coyote rifle. Now I use a CZ 527FS in .223 Remington or my Custom Mauser in 6.5.x55MM Sweede. The little CZ 527 is easy to carry and handle but the range is limited to about 175 yds with the 223 round. The sweede is a heavy rifle, more suited to benchrest shooting but is really overkill on a coyote.
I am looking for a 243 for the extra range needed past 175 yds cuz the desert is really open around here with long shots being the norm. However once in a while the sly dogs of the desert will surprise you. I was set up with my back against a rock on a hillside last year and my electronic caller was about 250 feet away from me. I had been calling for about 5 mins when a coyote trotted past me from behind no more than 15 feet away. His attention was on the twirling feather adjacent to the caller and he did not notice my drawing of my Ruger 327 Fed Magnum revolver behind him as he was gonna get that flying feather with the nice smell and the raucus sound. I shot him from about 45 feet and hit him in the back of the head with that .32 cal round. The round turned his head into mush and he dropped like a stone. Another coyote unseen prior to this suddenly stopped advancing on the lure and turned to leave. I caught the movement in my eye and I simply shot this one through the shoulders and he also went to coyote Valhalla. This one was about 40 yds away.
So you cannot always assume your shots will be at range around here. I am thinking a light bolt action in 243 would be the choice. I would love a CZ 527FS in 243 but I do not think that they make one.