I have used numerous Leupolds on large handguns in calibers from 44 Mag and 35 Remington through 375 Winchester and 45-70. I have never had one fail, in any fashion.
I have had a Burris fail, just one (probably 15 years ago, or so). The model had been discontinued, so they replaced it with the new (at that time) version with a very fast turn-around.
Leupolds are extremely light... I prefer that.
I agree that a 2x would be my first choice unless I had a specific application that warranted higher magnification, and after many years that's just not anything that I've ever needed.
I occasionally use 4x for load developement, but my handguns generally wear 2x when they go into the field.