After shooting today, and updating my load notes, I believe the powder I will be using for midrange 454 is HS6, it just really shines in this capacity. I have used 13.5 grains under a 325gr FNGC bullet from my Mountain Molds blocks, and it gives me less than 3" at 50 yards from a rest and open sights, works really well with the 340gr WFNGC bullet from my LBT blocks, the only place that Unique has beaten it is with the 289gr SAA bullet. I have found that 2400 works better for the region just below where H110 starts, not really midrange, not really full power. Absolutely shredded a 12" stump at 126 yards today. I do love the 454 Casull!