I think the closest to center targets will be fun and perhaps frustrating. Like someone said a lot will hit the trash.
Remember the final score will be an average of all targets. Shooting in the cold here yesterday I had some groups in the three inch circle I am using for targets and some out all with the same load. My POI changed about 1.5" after my rifle went from room temp to 15 minutes exposure to -30 temp.
An interesting point is that the boolits I shot yesterday were cast the day before.
So much for waiting for them to ripen.