Blatant Product Plug! lol.
Seriously if you have a use/need for a 22-250 the take off barrel is the way to go. Savage bolt guns uses the barrel nut to hold the barrel on so rent a a go no go headspace guage and screw it on the action. Reciever should be drilled and tapped so no worries about getting iron sights to set straight, don't put them on!
On the other hand if you need the "big Bore" rifle the same take off barrel is available in .308 I'm sure.
Like the man said what do you really want to do with this rifle?