Last year a good friend talked me into getting a Ruger SS Bisley .45 Colt/.45 ACP (he and our dealer both got one at the same time). They shoot EXTREMELY well with both cylinders after reaming the cylinder throats to .4525" (all three handguns had undersize cylinder throats). What at first was a bit "off putting" turned out to be a blessing in disguise. We all ended up with custom dimentioned cylinder throats. Here is mine with the .45 ACP cylinder:
My general purpose load for the .45 Colt is a 250 gr Keith with 8.5 grs of Unique. After I get my MiHec Cramer style bullet mould for the RCBS 45-270-SAA bullet (I should have it in hand in a couple of weeks) THAT will become my general purpose bullet. I am REALLY looking forward to that "wondrous time to come"...
Dale53