Sad to watch folks do that to themselves and to their family, for a fact. Not one thing you can do to help, unless they want to climb that mountain, themselves. Unfortunately, watched it many times over the years.
A fellow once told me how to quit smoking, put an open pack of cigarettes in you front shirt pocket, then never smoke another cigarette, it is then your will not the crutch of not having one to smoke. Exactly like having a "quit" bottle on the shelf, put the date on it, and never open it.
I think most of us have lost friends or family to the bottle, it is a tough loss. My grandfather was killed by a car one night, while carrying his beer across a highway in the dark.