As stated there are several powders that work fine in .45 acp. Powder is not the most important aspect of accurate .45 acp loads. Make sure your cast boolits are well filled out at the base with a sharp corner after sixing. Also make sure the base is flat with no voids. Next is a TAPER crimp of .469- .470 for the 200 g. Boolit. Lighter boolits of 185 and 160 g. require a taper crimp of .465-.466".
WST should work though I have never tried it. Powders I have proven are Bullseye, WW 231, Solo 1000, WW452 and VV310. All these are capable of less than 2" at 50 yards out of a Ransom rest.
I use Bullseye because it meters well in a progressive press and the last I bought was a special deal at Camp Perry. I bought 8# for $120.
I load 4.2 g of Bullseye with my cast 68 H&G with a taper crimp of .469. I have a slide mounted Ultradot with a 10# recoil spring. The old standard load was 3.5 g of Bullseye with iron sights.
You will not be able to tell a difference in loads shooting offhand because the error of the shooter far exceeds the actual difference in loads.