I like to tinker and consequently I have made loads for many of my different guns that are unique.
My 38 Specials get 358-311 over 4.0 grains of WW-231 or 3.5 gains of Bullseye, or 358-432's with the same powder charges, or else 3.2 grains of WW-231 under a H&G 50. However, my S&W 342 get 125 grain boolits over a piddly charge of Bullseye, (2.8 grains I think, but I am not certain0 it hurts when you crank off a full on 38. Those chaps with their .357 lite weights have my respect. Likewise, my S&W 52 gets 358-063 wadcutters seated flush and I don't use those in my other guns, though I suppose I could. I have 5 different 9 mm molds all of which get some use and each has a different powder charge. I have 9 32 molds, ranging from a 71 grain HP up to a 125-ish SWC for my 32 ACP's, 32 S&W Long's, 32-20's and 327's. Don't even get me started on rifle loads.
But to answer the original question, I shoot for best accuracy and complete reliability in each gun.