I have used TrailBoss in .45 Colt, 200 grain, .452 diameter. Pretty sure I used 6 grains, and that was right out of the LEE 2nd addition reloading manual. The TrailBoss did a fine job, but 8.5 grains of Unique seemed more to my liking. If I run out of Unique, I will not hesitate to use TrailBoss.