The thing with S&W revolvers is all the big ones hit the web of your hand really hard and this gets old fast. With MY m29 I could shoot 12 rounds of full power loads and I was done. Put Pachmayer grips of that one and it was much better.
Fast forward to now and all the S&W L and N and X frame guns have the same grip frame and take the same grips. if you look at the pic I posted above you'll see that there is 3/8" of padding in between your hand and the grip frame. This makes all the difference in the world.
Ruger figured this out from the get go and put that same style grip on their GP100/44.
Randy