Hey Scott and welcome to the forum!
Boy this will generate some responses, it is only like the most favored straight walled handgun cartridge to load for.
Basically, a LSWC will work, but I think the RF style boolits with the wide flat meplats on the nose work better.
One of the favored heavy for caliber boolits is the Lee C452-300-RF which runs about 320gr lubed and checked, these find much favor over full house charges of H110, but are really overkill for deer. Bear and hog, they are very effective. These would be loaded to the Ruger Only loads found in load manuals, 30,000psi max in a full sized RBH. Lots of recoil, but really more than necessary. I have shot a LOT of these boolits, loaded hot, they are fun for a while but really punishing on the hands in the long run, and again, much more than necessary.
The Lee molds for this boolit are hit or miss as to what size they will drop, and there is/was a group buy for the same boolit in an "improved" format with better crimp grooves, and a better fitting gas check shank. I would vote the improved design over the Lee although they both work.
A boolit I have been shooting recently and very impressed with are the LBT WFN designs, there are three in the 250gr weight, the WFN-PB, the WFN-GC and the shorter fatter almost a straight wadcutter with very slight ogival sides, the OWC-PB. For deer hunting these would be HARD to top, and don't need to be driven beyond 1200fps to be effective.
Cast in 50/50+2% with soft lube (Felix or randyrat tac1), this alloy just barely soft enough you can scratch it with a thumbnail, takes to Ruger's rifling and 1:16" twist like a duck to water, and never have to clean the bore.
There are my recommendations for a heavyweight, and a typical weight in .45 Colt.
L to R: LBT 250gr OWC-PB, LBT 250gr WFN-PB, LBT 250gr WFN-GC
320gr Lee C452-300-RF: