I have been loading and shooting a lot of the NOE 378 275gr FNGC, I was loading them over IMR4198 with very good results at 50 yards, but groups were really opening up at 100, so I sought out advice from a good friend, and made the switch to H4895, now I am getting 2.5" groups at 200 yards. Had some problems at first, namely my lube was migrating into the powder and I had a couple slight hangfires, problem was shooting in 112* heat, then too much dwell time in a hot chamber, alleviated that issue by tumble lubing with Lee Liquid Alox after I size and lube, it seems to be keeping the lube in place. I am very pleased with this combination, and at 285grs, it should be a good game taker. Now to work with my big 350gr FNGC bullet from an Accurate Mold, see if I can get decent results with it and H4895, to date it has turned in some super groups at 50, and about 3-3 1/2" at 100, would be pleased as punch if I could cut the 100 yards groups in half. I bought molds for this rifle to get some reduced recoil trigger time, with the intent of shooting it out to 75 yards, I knew I wouldn't be happy just doing that. Despite being an almost 9 lb rifle with the scope on, it has become one of my favorites, despite having enough jacketed bullets to last a lifetime, I still enjoy casting and shooting my bullets for fun and practice. It's like having a heavier 375 Win in a bolt gun.