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Over the past 40-odd years, I've owned/shot/hunted with many (but not all) different CF & RF single shot rifles.
They were:
* Trapdoor Springfield
* Browning M-78's & 1885's
* H&R/NEF
* Martini (BSA)
* Remington RB's, #4 & #1's
* Ruger #1's & #3's
* Savage 219's
* Stevens Favorite
* T/C Contender Carbine, Encore, TCR-83 Aristocrat's & TCR-87
* Winchester M-1885 Winder Musket
YMMV, but I prefer the break-open rifles (Savage 219, T/C TCR's) for hunting (I don't usually shoot at targets, unless zeroing a rifle) due to their relatively light weight & fast lock times.
For me, The Savage 219's issue chamberings don't offer a wide-enough choice, so my favorite single-shot is the T/C TCR-83 (like the one below).