I have to agree with BruceB. There are times I load for pleasure, performance and satisfaction and times I just need to make ammunition.
The purpose of the ammo is high on my list of how to load it. Loads for my hunting carry pistol, a Blackhawk in .45 Colt, are hand crafted one load at a time on a Rock Chucker as are my .44 Mag loads for a 14" Contender. I have a .45 Colt toolhead but it's been years since I used it. I bought some Hornady XTPs to put hogs down with but the cast boolits seem to work every bit as well so prefer to shoot my own boolits even if they cost the same. Besides, the cast boolit cartridges just "look right" in the drop belt rig that Springfield made for me.
Most of my centerfire rifle ammo is loaded the same way, one at a time, except for the kind of .223 you might want to stockpile and is loaded on a Dillon 550 until the parts to load it on a 650 arrive. Hunting and competition .223 is loaded on the RC.
When it comes to USPSA pistol match ammo, it is simply "manufactured" on a 650 with a case feeder at 900 rounds per hour. It's purpose driven and the purpose is to have enough for matches and practice. Dillons aren't the only thing. They're just another means to a different end.
David