I've been trying several powders with my 45colt BH. I've settled into Red Dot for target stuff using a 200gr rnfp because I have several thousand of those I use with my 45acp and it is something you can shoot all day and H110/w296 if I want to go heavy. I was using 2400 but I found that it is a sharper recoil than the h110 and produces a pretty interesting fireball when you get up to 19gr or so.