Yep, I did it today. I was fooling around with my shotgun press, a MEC, measuring the weight of the shot charge. I had the cap plugs out of the bottles so I could pour the shot and powder back in as I went. I needed to pull the bar and like a dummy, I tilted the bottles back just to see a huge pile of shot and powder dump out.
Guess where it all went? You got it, right on top of my keyboard! Oh well, it was filthy anyway. Had to take it all apart and wash the whole works. I saved most of the powder by screening out the shot.
My keyboard is pretty now until I dump something else on it.