Well, I didn't bother with the 1680 as it does seem to be too slow to work well. Maybe with a 200 grain or heavier bullet.
The good news: 300 MP appears to work very well...getting basically 100 FPS over a Lil'Gun with standard primers.
I worked up Lil-Gun from 13 to 15 grains (Hodgdon data) using 180 grain XTPHP and a Federal 200 primers (since they use a WSPM in the data). No pressure sings really at all. Case is sealing well. Relatively clean. Like I've observed with Lil'Gun it makes barrels very HOT. It maxed out at just under 1600 FPS from my 18.5" Remlin.
I worked up 300 MP with an extrapolated max load of 16.5 grains based off the 18.6 grain max load from Alliant for 158 grains and the 17.5 grain max load from Alliant for 170 grains. 16.5-16.4 appears to be a practical max load based on it being slightly compressed using starline brass sized in a Hornady die. 300 MP is not very compressible either. From 14.8-16.4/5 300 MP outclassed Lil'Gun in velocity, showed no hazardous pressure signs at all, and burned very cleanly. In fact, 300 MP, which usually leaves little yellow balls behind with the 158 grain loads showed NONE of this. Sealed as well as Lil'Gun did. Barrel did not get hot. Deviations were single digit (only did 3 shots at max though).
Theoretically this load should be fine in a L-frame or heavier framed revolver.
Maybe Hornady or Sierra will get a clue and test this load in their next edition (Alliant wont as Speer makes no 180 grain .357 bullet). I am becoming convinced that it is true that 300 MP doesn't need magnum primers. It seems to work better with Federal 100 than with anything else.
I also like how those very soft Federal 100 primers will show pressure signs earlier than about any other.
I also miked case webs and basically they were all the same after firing from starting loads to max.