I really like the Gen 5 .40s. The extra slide weight makes them run really smooth. Less selection in holsters though. Some holster will flex enough to accommodate but many are too fitted.
I mainly shoot 9mm these days but I got into pistol shooting when the G22/23 came out and really enjoy the cartridge. I have a few Gen2-4. Got a Gen5 22 and 23 last year and am enjoying them. If you like shooting .40 then I highly recommend the Gen5. I have a Power Pistol load that shoots like a laser. Shooting steel is more fun with the .40, for me at least.