I got 3 coyotes last night with cast in .223.
19.0gr of H4895 (Hornady cases, WSR) behind a checked and powder coated RCBS 55. 16" 1:9 twist AR (suppressed, under night vision). First 2 were just oppertunity yotes that loped into the pasture while buttoning up fence. Turned on the fox pro and wiggler while we picked up tools...sure enough we had a little song dog come tearing accross the alfalfa field adjacent to us and i got to the rifle in time to pop him at ~125 yards.
I like the pc cast loads for my truck gun because they arent as loud (even with the sandman S installed) from the cab of my tractor or pickup. Work good on vermin out to a couple hundred yards (1.5-2 MOA). 53gr vmax's work better.
Cast .225's work fine on yotes. Getting a load that shoots accurately enough to take one at anything over 100 yards is the tough part. Got to judiciously cull the little bullets if you plan on shooting anything resembling a group.