A little late, something to consider. The dwell time in the barrel plays a big part in POI. I found massive differences in POI between .44 Special velocities and Ruger/Contender only loads with my 14” Super .44 Contender. Granted, the difference was way more than 100 fps but I think the example is valid. Off of a bench and rest the 1600 fps loads shot more than 18” lower than the 850 fps loads at 50 yards.
I do abide by the philosophy of matching velocities with new batches of a powder.