I've tried a number of different bullet configurations through my .45 Colt Carbine (which will not reliably feed LSWCs), and I keep coming back to the Lee 452-255-RF projectile. I prefer it when PCd, but even if conventionally lubed, it is a solid performer. It feeds well, shoots nice tight groups, develops high (for .45 Colt) velocities when I use Ruger/TC-only loads, and smacks targets HARD, when it connects. The only other projectile that even gets close (in my carbine) is the Lee 452-230-TC.
I'm not sure what velocities a factory 240 gr. JHP obtains from a .44 Magnum carbine, but I would wager that my handloads are "in the same neighborhood" with either projectile. BTW, I get best accuracy with Hercules/Alliant 2400. I get slightly less, but still quite acceptable accuracy and higher velocities with either of the 4227s. I'm not a fan of H110/W296 in anything except .30 Carbine (for which it was originally developed) and avoid its use whenever possible.
I think LAND OWNER is on to something about the .45 Colt. Properly loaded, I think there is very little in north America that cannot be quickly downed by a heavy (240 gr. and up) flat-point cast .45 Colt projectile out to 100 yards. I don't think I'd try tackling the largest bears (Grizzly, Kodiak, Polar) with a hot .45 Colt, but that's about the only exception that I can think of.