The worst performance from a .22 center fire bullet on deer that I’ve experienced was a Sierra 52 gr bthp from a .223. I shot a cull 3 point in the chest facing me at 25 yards. It penetrated just far enough to rupture the heart; pieces of the bullet were found in the heart. About 6” penetration. He sidestepped and fell.
So, as Joyce Hornady once said, “At what point in the animals death did the bullet fail?”