My GP100 likes 190 gr FNGC (or 180 gr HPGC) Boolits with 16 grains H110 loaded at 1.600" COAL.
Shot 100s out of both my 6" and 4.5"
Cases fall out of Cylinder
Next lot of H110 I will have to start down a couple grains and work up again, it is what you have to do when running top end loads.