There have been some extensive threads on this subject, which you might turn up doing a "search" of the site. My experience was that I did experience chain fires-- a very unnerving experience. This despite the fact that my balls did shave a ring when loaded. So I went to Crisco, but found that by the 3rd shot it was melting out of the other 3 chambers and making a mess. Then I went to hi-temp bearing grease with much better results about the melting, but still had a chain fire. Next, I tried pre-lubed wads from Ox Yoke, so I had powder, ball, wad, grease. Still had a chain fire. I couldn't figure out why chain fires didn't seem to be a problem worthy of note in the gun books by the old timers, but was about ready to hang it up. Then, here on the forum, a member named Indian Joe (I think he's an Aussie) opined that the nipple/cap fit is all-important. It is true that many nipples don't fit the size cap they're supposedly made for. They seem to fit too tightly or too loosely, and European made caps can be slightly different despite the number on the container. In my case, I found that the No. 11 caps I was using, although pressed onto the nipples tightly, did not all seat as deeply on every nipple and one or two would be high. I discovered this by carefully cycling the cylinder and closely watching the recoil shield on the left side where I discovered that some would drag on the shield as they passed. The conclusion reached was that the chain fires were due to recoil setting off the chamber that had a high cap when recoiled back against the shield. An evaluation of each nipple's size and purchase of new nipples where needed solved the problem, as did the purchase of two cases of CCI No. 11 caps, so that everything is uniform. As a result, i no longer use the wads, but continue use the grease for leading, but would no longer fear the chain fires if it was just the powder and ball. One thing that I always use if I'm not just target practicing, shooting, reloading, shooting, on a C&B revolver to be left loaded for any period of time is the Blue & Grey cap guards. They do two things: Assure that the cap remains in place on the nipple, and provide some waterproofing for the cap.
DG