1st - Powder Coat EVERYTHING! That eliminates any worry of leading - if your boolit is sized for your barrel first. PC is amazing, but cannot cure poor fits - all the time.
I shoot GOBS of 45 LC's in anything from 180 to 300gn (revolvers and long guns) and the alloy I use is somewhere between 9-12 +PC. It varies a tad with every batch. Since going with PC 8+ years ago, I don't worry about mixes or hardness at all. Just good clean lead-free smoke-free accurate (for me!) shooting every time.