Seeing some badmouthing and degrading some for their opinions. Not really normal for castboolits, and really childish...
For someone to ask the question as the theme of this thread, indicates they are very lacking in reloading theory, methods, and general practice. The "Well I reloaded a 277 gr LRN over some 4227 in my 38 Special...", posts are worthless and misleading. I've seen .22 lr shot through a .17 cal barrel. Good practice for a new shooter? I agree with Mr. Bannister, if there is no published data for a particular combination of components, there usually is a reason, and reloading manuals are definitely not just meant for the uneducated masses! Some reasons may be a too inefficient load, impractical, and some may be bordering on dangerous (or just plane stupid). The OP obviously has very little experience (no big deal, we all gotta start sometime) and to tell him to extrapolate data from a different bullet/cartridge/gun load is misleading, irresponsible, and a disservice to the new guy. Some of us more experienced reloaders have "played", experimented with "out of the norm" reloading, but most of us knew what were doing and had an idea what to expect. Just because an experienced reloader can get away with something out in left field does not mean he should suggest that to a neophyte reloader...