I must be old, I reload for my S&W 25-5 6" barrel, ( still have the original box and wax wrapping paper, warranty forms ). My 1977 Hornady Handbook/ manual page 363 shows a max load of 8.8 grs Unique for a 250gr hollow point. No cast bullets listed in that manual for the 45LC., at that time. A load that I used "1984 vintage " was Lyman #454424 255gr SWC with 10.0 grs Unique. This load was from an article Loads for the 45 Colt by John Wooters, 1984 G&A Handgun Annual page 45. ( I still have the magazine ). I have used the same Lyman #454424 with 18.5 grs of 2400 , and old Elmer Keith load, with no problems, and the Oregon Trail 255 gr SWC keith style boolit. 17 grs of 2400 gave about 850fps with the old Speer 250gr SWC. Last my more modern Lyman 47th Edition Handbook page 455, shows # 454424 255gr SWC and 10.2 grs of Unique for 1162 fps ( out of a 10" Thompson contender barrel ). My more modern civil liability manuals ( 2 ) show lower, safe loads for Unique Powder and separate loads levels for the 25.5 6" barrel, Contender 10" barrel and Ruger Blackhawk and original Ruger Vaquero. Don't tell anyone but I've used 18.5 grs 2400 in my original Vaquero and love it. Unique gives great accuracy with moderate loads.