I just thought I'd mention something we found out recently, might help out. If you have expensive prescriptions and high co-pays/deductibles, it might be worth calling the drug manufacturer to see if they have any sort of assistance program.
Our insurance changed at work (resisting making negative political comment),and we paid out a small fortune last year. This year we have an HSA with a high deductible and no provisions for co-pay, everything out of pocket for the first few thousand.
My young son requires an expensive medication that costs over $30k/year. We were looking at paying a decent chunk both before the deductible is met and then our percentage after insurance. The doctor said to call and ask the drug manufacturer about "co-pay assistance", so my wife did. The doctor said another patient had a $75 co-pay and the drug company covered all but $5.
Long story short: they will cover almost the entire cost that the insurance doesn't, including our deductible! It's not necessarily charity; I expect they would rather make a little less than have a patient switch to something else. I assume that the bulk of the expense with drugs like this is the development cost, rather than cost of manufacture. Either way, it's a huge load off of us. I thought I'd mention it here in case anyone else is in a tight spot like this and might be able to see if this would work for them also.