I've never had much luck with the Keiths in 45 Colt in the sub 1000 fps range, either. My experience has been that you may find a moderate velocity Keith load that shoots reasonably well at 25 yards, but none of them have remained stable for me out past 100 yards. For those sub 1,000 fps loads I have had much better luck with RF designs, like Lyman 454190. Shoots well close and remains stable at longer distances.
My Keith experience was with 240 gr (452423), 255 gr (454424, Catshooter group buy), a 270 gr NEI design and a 325 gr design from Dry Creek. I have never tried any of the RCBS offerings.
I suspect the trick to the Keiths is to push them much harder from the start (1200+ fps) and/or don't expect much from them at longer ranges. I would be interested in hearing others experience with this (45 Colt Keiths at modest velocity).
-ktw