My favorite .45 Colt Loads for plinking or SD in the Woods is either the Lyman 452664, 250 grain RNFP or Lee's .45-250-RNFP on top of 9.0 grains of Alliant's Unique. These shoot with deadly accuracy out of my Anaconda.
With my SAA's using Black Powder in the .45 Colt Case, it's 40 grains Goex 2Fg Compressed to seat the 250 grain PRS Big Lube Boolit touched off with a magnum Large Pistol primer. If using the Schofield case, it's 30 grains of compressed Goex 2Fg and the same PRS big Lube boolit or the Lyman 454190.
For real serious work it's 17.5 grains of 2400 and the Lyman 454424 Kieth style SWC or Lyman's 452490 gas checked SWC. Both are hard hitting and very accurate.