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Speer manuals #9 and later have tested data for .45 Auto Rim with 250-260-grain bullets. They top out at 6.2 grains of Unique with the 250 grain lead SWC for 824 fps. I would not be inclined to exceed that. In the .45 ACP with 260-grain JHP max. is 6.4 Unique for 822 fps.
I use 5.5grs Unique under the N.O.E. version of the #452423 drops at 245grs from My alloy.
My pin load in my 45 ACP Long Slide is a Lyman 45 Auto Rim that is supposed to be dropping 236 but actually drops 252g. Driving band set out 1/8” so it feeds, just sticks a bit at lock up. Like throwing a brick bat.
I have one pound frame weights, under the grips.