howdy-
sooo, i use the 375 winnie, loaded to about your specs actually, 20gr of 4198, 245gr commercial hard cast,.... its tough.
i down loaded for a pleasant plinker an capable deer round, open sights i can just hit a gong at 150m , an that is my absolute max, 100m is preferred and under... i find the front bead takes up too much animal or in thick bush limits placement an confidence, i filed this down thinner an helped alot... i also use williams peep sight an my 100m grouping inproved dramatically.
I have shot larger deer similiar to Elk, called Sambar deer, lung an heart shots often resulted in pass through and running short distance - similiar to bow hunting.
ive not shot them with the 'lower' load yet , maybe this month some time! but the smaller deer have DRT an also lunged an ran out an piled up.
Your penetrtion im goin to say will be 100% in most instances within 100m or so, an Distance will be pending how far out you can consistantly hit a 10 inch round gong say, from different distance first time each time, after 150 my trajectory cancels me out for point and shoot.... (if loaded hot 375 would extend this but i dont need it)
https://i.imgur.com/ZvOaWyG.jpg