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If I was loading a batch of ammo to be used strictly for hunting I'd weigh the bullets just to be sure they didn't have any voids.
Other than that? No. I don't weigh pistol bullets and I don't even sort .38 bullets for rejects. If it's filled out well enough to stuff into a case, it gets shot.
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Lots of theories about this. IMHO. calculate the % of 1/2 gr or whatever step you want. Take your fps into account (voids/bad boolits, etc.). HV shooters consider the RPMTH problem. My opinion is most small weight difference is caused by poor quality pours (L.G.s, etc.), not voids. 12gr/450gr = 3% and no problem but it's not going 3K fps. 3% in 38 going 1K fps? I don't think there is a problem - are pistol sights good enough at >25 yds to make a difference?