If you want something to cease breathing quickly, use the biggest meplat you can use for the caliber.
All of these are loaded in 45 Schofield brass, the three on the right are all 250gr LBT offerings, of the three my choice for hunting is the far right load, LBT 250gr Ogival Wad Cutter.
This load chrony'ed at 1200fps, just under 23kpsi pressure (according to QL) did not have the ability to do any gelatin testing but most of us have seen enough gelatin results to agree the far right would probably create the biggest cavity.
Attachment 303973