Personally, I think a 265 gr bullet in .45 caliber is way way too light. I'm sure an elk can be killed with it, but why such a light pistol bullet in a large bore rifle?
I am not a fan of the extra large size meplates and certainly not water quenched hard bullets etc. I guess there are multiple ways of doing things, but my way is soft and heavy, and it works very very well.
This little springbok was shot with a 535 gr bullet that did not pass through, yet, oryx, elk, hartebeest and other animals have all had pass throughs dependably with the same bullet and load. There is only so much you can guess about how a bullet will preform. Keep in mind it is a guess at best, not a certainty. Shooting critters is inexact business.
http://www.public.iastate.edu/~jessi.../Springbok.jpg