How many times can I

[Pighunter]

Just wondering how many times I can reuse my 300 WM brass? I know it depends on how hot the loads are, but just kind looking for a general number.

[charlie b]

I would venture to say anywhere from 4 to 10. Could be more if you anneal them every now and then. Also depends on how big the chamber neck is cut and how much you resize. And, yes, it can depend on the brass mfg.

[poppy42]

Are usually go with about eight times . Like you said depends on loads, quality of brass, caliber, etc. but the closest I use for a general rule of thumb is eight times.

[bmortell]

some of mine split at 3-4, never annealed

[georgerkahn]

Pighunter -- There are myriads of variables, including even the manufacturer of your brass. I have included here a chart with some manufacturer's alloy -- numbers are in percentages -- for you to see this. Another variable is the chamber size of the firearm you are employing, not to take for granted its head-space. (As well as variables you aptly mentioned).
249378
Steel gets softer as it is worked -- e.g., bend a paper clip -- while just the opposite phenomena occurs with brass. Each and every time you work (e.g., fire) a round, the brass is expanded, then shrinks a tad as it cools. We then put it on the reloading press and exercise it more. For this reason, I'm a firm believer and do-er ;) of annealing. For military loads in .30-'06, I anneal mine every third shooting, and generally retire the brass after its ninth. Before I began annealing, I'd get a modal four firings.
Toooooo many variables ;) to answer your question with much more than a "(slightly) educated guess". I hope this helps. I will add that, after you shoot some, I surely will enjoy your hopeful posting your actual experiences.
BEST!
geo

[Pighunter]

Great information, Thank you all.

[Norske]

How completely you resize has another big effect. I size my cases minimally, meaning I can't close the bolt with my index finger, but my thumb closes it easily. In other words, size for the shoulder length, don't always size to the bottom of the resizing die. My cases usually fail due to cracked necks, not separation above the web.

[gnostic]

It's the primer pocket that goes first. When the primer seats easy, I toss them...

[Slugster]

I reload bottlenecked rifle cases from 6 to 10 times. Straight wall cases...a lot. I'm still using the 200 PMC .44 magnum cases that I bought with my 1st Ruger Blackhawk in 1982. Lose a case to split neck once in a while, but still going strong. Anneal every 3 or 4 loadings and brass will last a lot longer. Size the cases to your rifle's chamber, don't just "cam over" on the press. I only partially re-size revolver cases, full resize pistol cases.