I finally got around to making up some dummy cartridges to see if they would chamber in my two 625's (one is a 5" 1989 Model 625-6 and the other is a JM Special 4" barrel 625-8).
Some have reported problems chambering heavy bullets in their 625's. I loaded up six dummies with the Lyman 452664 (250 grs with my alloy) roll crimped in the crimping groove. They chambered just fine. However, they were sized at .452" and .451" might have been a slightly better fit for the cylinder throats (could feel just a bit of resistance when I loaded each chamber). This bullet design has a "full diameter nose" that extends slightly past the case mouth and is bullet size (in my case, .452"). This is a picture of the bullet for those who haven't seen it (also labeled Lyman's Cowboy Bullet for .45's):
I have found this particular bullet gives excellent results in my Ruger Bisley Vaquero with both black and smokeless powder (with suitable BP Lube). I have shot scores as high as 92x100 at fifty yards slowfire with black powder in competition. I have cracked a 100x100 at the 25 yard distance on the timed fire target. So, I believe it to be an excellent choice for a heavy bullet (for the caliber) in a .45 ACP revolver.
Frankly, I personally have little need for a heavy bullet in my 625's. However, I have academic interest in the possibilities. Others have safely loaded to 1000 fps with similar bullets out of similar revolvers. That should take care of most any woods deer hunting situation. I have .44 magnums and .454's for "heavy work" but frankly most of my deer hunting days are behind me (getting too dern old to drag a deer out of the woods and too prideful to have someone else do it for me). However, I KNOW this would do the job if needed.
I will be reporting on use of the Lyman 452664 bullet in my 625's later on. I plan to have chronograph data with the report.
Incidentally, the September 2008 issue of Gun Tests Magazine, has an interesting article on three .45 ACP revolvers. I pretty much agree with their choices but it is pretty amateurish in several areas. They report on the S&W 625 (Model of 1989), the Night Guard 325, and the Taurus Tracker.
I have been working with my two 625's this year and also working with my Taurus Tracker in .45 ACP. The Tracker is an interesting revolver. Mine has a 4" ported barrel, has a good trigger and handles quite well. It has some idiosyncrasies - it works perfectly, every time with .45 ACP cartridges used without the furnished full moon (five shot) clips. Of course, you have to pick the cases out of the chambers with your finger nails. The clips appear to be made of spring steel and are VERY thin. It would be easy to cut your fingers on them. They are less than positive in holding the loaded rounds in position. The Tracker is different from the traditional Colt and Smith and Wesson .45 ACP revolvers - it does NOT have sufficient head space to allow the use of .45 Auto Rim cases (Gun Test incorrectly thought that was because the cases were expanded too much to use. Not so, there just isn't enough room for the thicker rims of the Auto Rim cases). That is a major faux pas on the part of the authors.
I discovered that the Tracker's head space was EXACTLY correct for the rim thickness of .45 Colt cases (but of course the chambers are too short for this case). The .45 Cowboy Special case is PERFECT for the Tracker. They have the same capacity as the .45 ACP and Auto Rim but the case head of the .45 Colt. So, they take the place of the Auto Rim cases that I use in my 625's and end up serving the same purpose.
My Tracker (can't speak for all of them) will not allow a loaded round to fully chamber if ANY of the bullet shoulder extends past the case mouth. This is just a minor annoyance to me as I just load the .45 Cowboy Specials up just for the Tracker. The Tracker makes a fine trail gun and packs easily. My Tracker is a VERY accurate piece with cast bullets (boolits to you all).
My 625's, as I have reported here ad nauseum, are just flat wonderful revolvers. Accurate, easily handled with adequate power for most any reasonable use. They are as good a target revolver as money can buy. The .45 ACP or Auto Rim case is an extremely fine platform for target loads up to and including decent hunting loads (not a magnum but adequate power for many purposes, nonetheless).
Dale53