My quick scan of the preceeding posts revealed that no one addressed that if the cartridge loaded with an un-sized bollit will not chamber in the firearm by gravity alone then you will need to size down the boolit until it does so. The reason being that if the cartridge is so tight in the chamber that it cannot release the boolit easily upon firing then chamber pressures may increase to an unsafe level. The excellent Lee Reloading Manual answers this question. Slugging the barrel and throats will be the best place to start if you experiance leading or inaccurate ammo.