Hi Vance. I also use Lee molds. My 357, 45 and 30carbine are double cavity. My 8mms are single cavity. I have found, that contray to popular belief, the Lee aluminum molds take a little while to heat up evenly. And cool rather quickly. I now use a hot plate, at the highest setting, to heat the mold and run my temps between 780 and 800.
I have bad eyes and start to get a little crosseyed after dropping 30 to 50 boolits from my Lee 20 pounder. I then take a break. Throw my sprues back into the pot. Set my mold on the hot plate. Check my boolits and throw the rejects back into the pot. Smoke a cig and drink a beer. Check to make sure my temps are back up to 780 or 800 with my RCBS thermometer. Than start casting again, until I start getting a little crosseyed again. Then I do the process over.
I have tried different alloy temps with the Lee molds and it doesn't seem to keep the mold hot if lower than 780 to 800. At 600 or 650 I can drop 10 or so boolits, with the first ones coming out a little frosted, but after the 10 or so, they start getting wrinkles because the mold is cooling down.
Now with your molds dropping 400gr boolits, you may find the mold may heat up a little quicker. Because there is less meat around the cavity. But they may also cool down quicker. Because there is a little less meat around the cavity to hold the heat.
You may need to run you alloy temps a little higher. 800 to 820. Gives you a reason to use that RCBS thermometer.
I would start with a really hot mold and the alloy temps being around 780. Drop a couple of boolits and check them. Drop 20 more and check the last two. If all is right, roll with it. If you're starting to get some wrinkles, however slight, crank your temps up a little. On your alloy.