Guys, I've wondered, but not done any actual testing to decide, so I think I'll cheat by looking at you old guys' papers:
If, like me, you're using a Keith 454424 mold, do you adjust your charge by bullet weight, or just use the existing loads for that mold? A lot of people claim they get a 250 gr. bullet from that mold. Some claim 260, some, 265, etc.. Mine generally drop about 268. Hence the question.
Whaddya say, grey hairs?