Yes! I used to shoot out to 300 yds occasionally but only on dead calm evenings. I didn't have my rifle set up exclusively for this purpose so figuring out the hold over was always a challenge. I shot Federal blue box 40 grain from a Savage BTV at a 6" steel plate.
Once I remembered the hold over it wasn't particularly difficult. But variable wind would be a completely different experience.
My hold over was probably more like 30".