A six-shot revolver with a three-inch (or even four-inch) barrel would drive either a 50-grain (up to 60-grain) .251" bullet at velocities between 1300 and 1400 fps (depending on barrel length).
This would make a great varmint cartridge and would drive a Lehigh (fluted) bullet up to 28 inches in gelatin. A hollowpoint bullet may tend to open violently and stop as does a lightweight (185-grain) .45 Super.
Would anyone care to see such an experimental cartridge developed?
Inquiring minds would like to know.