Some 55 years ago when most rocks were still hardening Mr. Ackley wrote a monthly gunsmithing column for a gun magazine, GUNS & AMMO, IIRC. In answer to a question, "Which of your AI chambers worked best?", he said the .250 Savage was best and most of the rest really didn't make enough difference to make a difference; that killed my desire to AI my beloved .30-06. And I'm still glad I listened to the master about it.
Sure, we can fire factory -06 ammo safely in it but the pressure would be low so velocity and trajectory will be poor and accuracy probably wouldn't be great. Any resale value of an AI rifle would likely be very low too.
Ackley's really aren't very popular, handloading would be necessary and we are a very small group. Which of us is going to be interested in buying a used hunting rifle that has probably been hot-rodded all of its life?
Bottom line, I figger if God wanted me to shoot a .300 mag that's what He would have led me to purchase to start with.